New publication in Coordination Chemistry Reviews journal entitled “Antitumour activity of coordination polymer nanoparticles” authored by Dr. Salvio Suárez-García as a first author, Dr. Fernando Novio and Dr. Daniel Ruiz-Molina in collaboration with Dr. Félix Busqué and Dr. Ramon Alibés from the Chemistry Department of UAB. The review has been published in Open Access, thus allowing for free access to all interested researchers.
In this review article, the authors discuss the use of coordination polymer nanoparticles (CPNs) to treat cancer. In that way, an exhaustive compilation of reported systems is classified depending on the antitumoural activity employed: encapsulation of drugs, stimuli-responsive, metal chemotherapy, photodynamic therapy and theranostics, among others.
Overall, the review focuses the attention on:
· Synthesis and characterization of nanoscale coordination polymers (NCPs).
· Antitumoural activity of NCPs.
· Multitreatment/theranostics nanoparticles.
· Biological interactions of coordination polymers.
· Metal chemotherapy and drug delivery.
Finally, a critical discussion regarding challenges and future steps needed in the area is presented to encourage researchers to overcome and fill the gap between the laboratories and the clinics.
ABSTRACT: Nanoscale coordination polymers (NCPs) have fascinated researchers over the last years. Their intrinsic theranostic properties of metal ions and organic ligands, the encapsulation of several drugs/biomolecules with excellent yields and the surface functionalisation, enhancing their biocompatibility and targeting, have remarkably impacted in prospective drug delivery alternatives in medicine. Moreover, the properties and characteristics of these nanoparticles (NPs) can be fine-tuned thanks to the synthetic flexibility of coordination chemistry. For all these reasons, the number of examples published has grown exponentially over the last years, embracing different disciplines such as molecular electronics, sensors or nanomedicine, among others. Specifically, significant advances in antitumoural applications are reported, one of the areas where this novel family of NPs has experienced a considerable advance. NCPs have accomplished a high sophistication degree and efficiency as theranostic nanoplatforms (i.e., drug delivery carriers and bioimaging probes) with long residence time in the bloodstream, targeting capacities and remarkable cellular internalisation. In this review, an introduction emphasizing the advantages of NPs for cancer treatment is included. Later on, the most representative examples of NCPs for antitumoural applications are described grouped into six mean representative areas: i) encapsulation approaches, ii) stimuli-responsive NCPs, iii) metal chemotherapy, iv) photodynamic therapy (PDT), v) unconventional therapeutic approaches and vi) theranostics. Particular emphasis is given to understand the encapsulation/release properties of these particles at the nanoscale and their interaction with biological environments, highlighting any limitation and challenges that these systems are facing from a clinical translation perspective and envisioning possible future trends and areas that will deserve further attention for the following years.