Today Dr. Xiaoman Mao has presented her Doctoral Thesis entitled “Platinum-based Nanostructured Polymers for Glioblastoma Treatment“. The thesis has been carried out within the Materials Sciences Program of the Universitat Autònoma de Barcelona (UAB).
Dr. Xiaoman Mao has developed her Thesis on Nanostructured Coordination polymers (NCPs), which have emerged as a new family of nanoparticles with interesting properties due to the versatility of coordination chemistry. The potential multifunctionality of these nanosystems and the facility for modifying their physicochemical properties opens new perspectives in different fields, including medicine. The recent advances have shown the potentiality of NCPs as smart drug delivery systems, bioimaging probes or a combination of both.
The Thesis has been focused on the design, synthesis, and characterization of platinum-based NCPs for exploring the possibilities of these nanosystems in the treatment of cancer and particularly in the treatment of glioblastoma. Different platinum-based coordination polymers have been obtained and evaluated for biomedical use based on different studies in silico, in vitro and in vivo. The synthetic methodology, the proper selection of precursors and reaction conditions, and the study of the final physicochemical and biological properties have centered the work carried out.
The Thesis Comitte has been formed by:
President: Dr. Patrick Gámez Enamorado (ICREA, Universitat de Barcelona – UB)
Secretary: Dr. Óscar Palacios Bonilla (Universitat Autònoma de Barcelona – UAB)
Vocal: Dr. Alejandro Baeza García (Univerisdad Politécnica de Madrid – UPM)
Her directors Dr. Fernando Novio and Dr. Daniel Ruiz-Molina and the whole Nanosfun family are proud of such a good job!